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Discussion in 'Provenpeptides' started by Vfusion, Jul 7, 2018.

  1. Vfusion

    Vfusion AdministratorStaff Member

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  3. Aton

    Aton Super-ModeratorStaff Member

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    Love to here how it works out.


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  4. HeavyHanded

    HeavyHanded Well-Known Member

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    What exactly is it supposed to do? Gh effects?
     
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  5. Vfusion

    Vfusion AdministratorStaff Member

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    GW-501516 is a drug that acts as a PPARδ modulator. GW-501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. GW-501516 activates the AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue.

    GW-501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions.

    GW-501516 has also shown to dramatically increase endurance and recovery. In rats, binding of GW501516 to PPARδ recruits the co-activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure.

    In obese rhesus monkeys, GW-501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.

    GW-501516 Uses:

    GW-501516 has many benefits but has two primary uses. The most common use of GW consists of the extreme amount of endurance and recovery increase. The results with GW-501516 use regarding endurance increase are staggering. GW was banned by the WADA (World Anti Doping Association) in 2009 because it provided such a large advantage to users over their competition. GW has shown to be fast acting with drastic results. A user can expect to see an endurance increase within a few days of use. GW-501516 provides continuous increases in the VO2MAX, allowing an individual to provide maximal output during exercise, thus obtaining the name, “The Ultimate Performance Enhancer.” The common dosage for this type of result is 20 mg a day with 14 weeks of continuous use

    The other main use of GW-501516 is to aid in fat loss. GW-501516 has shown to melt away fat at a rapid pace. Another strong component of GW-501516 is that it is non catabolic, meaning it allows a user to lose fat and not have to sacrifice muscle. Many people that are on a fat burning diet are sacrificing a lot of muscle. GW-501516 allows a user to hold on to much more muscle than a standard fat lass diet or other fat loss compound would allow. GW-501516 also shines when ran in conjunction with other SARMS. When stacking GW-501516 with Ostarine and S4, users can add lean muscle while still losing weight and body fat. This makes GW-501516 highly desirable for many. The most optimal dosage for fat loss is 20 mg a day but users will still be able to receive this benefit at 10 mg a day.

    GW 501516 can be ran in 8-12 cycles and can also be ran in conjunction with any SARM, steroid or supplement. As with any other steroid or supplement, it should be cycled properly to avoid any possible side effects and the keep it as effective as possible.

    The Science of GW-501516 Fat Burning

    GW-50156 regulates fat burning through a number of widespread mechanisms. GW-501516 increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization. This shift changes the body’s metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity.


 GW-501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. 

In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure. Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW-501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1.

    Cholesterol Improvement

    An often overlooked benefit of GW-501516 use is the ability to treat poor cholesterol. GW was originally formulated to treat people suffering from cholesterol problems and has shown to significantly increase HDL (good cholesterol) whle reducing LDL (bad cholesterol).

    Dosing Timing:

    GW-501516 also has a very long half life, so it can be dosed once a day or split 12 hours apart. The most effective method of dosing is to take it in one serving, 30 minutes prior to working out. On non workout days, once a day dosing in the morning is the best method. If a split dosage is used, 10-12 hour splits are optimal.

    Side effects:

    There are constant debates and many studies arguing the potential side effects for a user. There are studies showing that GW-501516 has caused cancer in rats while other studies refute it. The ONE study that was conducted that showed this issue was deeply flawed and refuted time and time again. GW-501516 dosing was not only abused but ran at insurmountable amounts of time within this study. When ran properly, it has actually been used as a cancer treatment. There are no known side effects associated with GW use and the only need to cycle off is so that one’s body does not acclimate or desensitize to use. There is no suppression, no toxicity and no other common side effects. This makes GW even more desirable amongst the bodybuilding community.

    Benefits of GW-501516:

    Extreme increases in endurance and recovery
    Extreme fat melting
    Long Half Life Making Dosing Optimal
    Lowering of Bad Cholesterol and Increasing Good Cholesterol
    Minimal Side Effects
    Can be ran up to 12 weeks
    Stacks well with everything
    Non catabolic
    Excellent energy
    Excellent overall sense of well-being and feeling
     
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  6. HeavyHanded

    HeavyHanded Well-Known Member

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    ^^^ Thank you. Holy shit this stuff sounds great. Looking forward to your opinion on it.
    Please update frequently.
    Thanks again.
     
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  7. Aton

    Aton Super-ModeratorStaff Member

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    I’ve have thought in the past it could be an amazing add on to a keto cut or diet.
    It seems to work off of the same idea of utilizing fatty acids for fuel and probably to a lesser degree body heat energy.

    Knowing is mobilizes fatty acids it would starve cancer cells as it would also reduce glucose (bg) which cancer feeds on to nourish and multiply.

    Having to quick endurance would be great too if u need to kick up ur cardio to burn through some of those Calories or take less time between sets.


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  8. Mountain-Man

    Mountain-Man BRPHARMA RepVendor Rep

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    Extreme fat burning well I know I'll be buying some from provenpeptides then in sold if you say it's quality
     
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